Fluigent - Microencapsulation Fluidics System

Was der Auftraggeber sucht

1.0 DESCRIPTION This is a combined solicitation for commercial products and commercial services conducted in accordance with RFO FAR Part 12 – Acquisition of Commercial Products and Commercial Services, using the simplified procedures at RFO FAR 12.201-1. This notice serves as the solicitation. Quotations are being requested, and a separate written solicitation will not be issued. The Department of Health and Human Services (HHS), National Institutes of Health (NIH), National Institute of Environmental Health Sciences (NIEHS), intends to procure, on a sole source basis, a Fluigent Microencapsulation Platform, including the required microfluidic modules, pumping and droplet-generation components, computer and software, installation, and training from the manufacturer, Fluigent, 73 Princeton St., Suite 310, N. Chelmsford, MA 01863. The NIEHS Division of Translational Toxicology (DTT), Mechanistic Toxicology Branch (MTB), conducts laboratory research to identify human health hazards and understand environmental toxicity through hybrid basic and applied science approaches, including the development of new approach methods (NAMs) for toxicology research. The MTB is advancing innovative toxicology research using advanced cell systems, including human tissue chips and three-dimensional (3D) organoid and microtissue models, to understand the adverse effects of chemicals, drugs, and natural products and to develop innovative solutions for translational toxicology research. The Government requires a specialized microencapsulation fluidics platform capable of combining liquid-form alginate with human cell suspensions under highly controlled conditions to generate droplets that form eggshell-like alginate capsules around suspension cells. This controlled encapsulation process is required to support the formation of 3D microtissues, organoids, spheroids, and other advanced cell models for translational toxicology applications. The required system includes a specialized combination of microfluidic pumping and larger-size droplet-generation capabilities that can reliably produce alginate-encapsulated human cells at the scale and level of control required for the Government's research activities. The Government intends to procure the Fluigent Microencapsulation Platform on a sole-source basis from Fluigent. The required system includes a suite of modular microfluidic components that are integrated to provide controlled pumping, mixing, and droplet generation for alginate encapsulation of human cell suspensions. The requirement also includes the associated computer and software, installation, and training necessary to establish and implement the system within the NIEHS laboratory. Installation and training will be performed by Fluigent representatives at the NIEHS facility to support proper system setup, configuration, operation, and rapid onboarding of laboratory personnel. The system will operate independently of NIEHS information technology systems and will not require NIEHS IT support. Acceptance of the system will be demonstrated by the successful formation of alginate-encapsulated human liver microtissues within the NIEHS laboratory. The NIEHS conducted market research to identify potential sources capable of meeting the Government's specific technical and operational requirements. The market research considered commercially available microencapsulation and microfluidic technologies capable of providing the required combination of controlled microfluidic pumping, larger-size droplet generation, alginate encapsulation, and integration necessary to produce human cell-containing microtissues for translational toxicology research. Based on the market research conducted, Fluigent was the only vendor identified as capable of providing a commercially available system with the required combination of capabilities and configuration necessary to satisfy the Government's requirement. The required combination of microfluidic pumping and…

Sprache dieser Bekanntmachung: English. Titel und Beschreibung erscheinen genau so, wie der Auftraggeber sie veröffentlicht hat.